MK-677 (Ibutamoren) - 25mg (preorder)

What is MK-677 (Ibutamoren)

MK-677, also known as Ibutamoren or Nutrabol, is a non-selective ghrelin receptor agonist and also stimulates the secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Its chemical structure allows it to be administered orally with a long half-life and stable plasma levels.

Researched effects and interesting facts

• Increase in GH and IGF-1: Studies show an increase in levels of up to 60–100% after long-term administration.
• Muscle mass: Research on older individuals shows preservation or increase in muscle mass without a change in cortisol levels.
• Sleep quality: Improvement of deep sleep and the REM phase, which is attributed to the effect on GHSR receptors in the brain.
• Regeneration and healing: Increased IGF-1 levels can support tissue repair, which is being studied, for example, in fractures or injuries muscles.
• Neuroprotection: Research is ongoing on the possible effects on cognition, memory, and prevention of neurodegenerative processes.

How does MK-677 work

MK-677 binds and activates the ghrelin receptor (GHSR) in the hypothalamus, which leads to increased secretion of growth hormone. The result is stimulation of IGF-1 production in the liver and other tissues. In laboratory conditions, an increase in GH and IGF-1 levels is observed without a change in cortisol levels, which suggests a more specific mechanism of action than with classic growth hormones.

Dosage in studies

MK-677, also known as Ibutamoren, is an investigational compound that stimulates growth hormone secretion through ghrelin receptor agonism. It is often the subject of research for its potential to support muscle growth, recovery, and sleep quality.