What is 9-ME-BC?
9-ME-BC (9-methyl-β-carboline) is a β-carboline derivative, studied primarily for its effects on dopaminergic neurons. In experimental models, it has been associated with promoting neuronal differentiation, modulating dopamine, and influencing signaling pathways related to neuroplasticity.
It belongs to small lipophilic molecules that can penetrate biological membranes and, under laboratory conditions, influence mitochondrial processes, including the respiratory chain and oxidative stress.
In the context of research, 9-ME-BC is being studied for its potential in the areas of cognition, motivation, attention, and fatigue resistance, but always within a strictly experimental setting.
Researched effects and interesting facts
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Dopaminergic modulation: Possible influence on dopamine availability, with impact on motivation and psychomotor activity in models.
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Cognitive functions: Parameters of learning, memory trace, and attention are investigated in experimental settings.
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Neuroplasticity: The observed signals suggest support for neuritogenesis and synaptic adaptation.
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Mitochondrial support: Evidence for improved bioenergetics and resistance to oxidative stress.
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Fatigue and stress: The effect on perceived fatigue and coping with stress under experimental conditions is monitored.
How 9-ME-BC works
In experiments, 9-ME-BC has been associated with modulation of the dopaminergic system, including the expression and function of transporters, enzymes, and receptors that affect the availability of dopamine in the synaptic cleft.
Another mechanism being investigated is the promotion of neuritogenesis and synaptic plasticity, probably through influencing transcription factors and mitochondrial bioenergetics; thus, it may contribute to more efficient information processing at the level of neuronal networks in model systems.
Some studies report an effect on oxidation-reduction balances in neurons and a potential reduction in reactive oxygen species, which may be relevant in investigating neuroprotection under stress conditions.
Dosage in studies
The values listed are derived solely from research studies and are not intended for real-world use outside of a laboratory environment.
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Dose: 5-20 mg daily (model protocols)
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Form: oral (capsules)
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Frequency: 1x daily according to study objective
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Duration: 4 – 8 weeks within experimental protocols
9-ME-BC (9-methyl-β-carboline) is a heterocyclic compound from the β-carboline group, which in laboratory research is mainly associated with the dopaminergic system, neuroplasticity, and mitochondrial metabolism of neurons.
| Parameter |
Value |
| Form |
Capsules |
| Contents |
15 mg 9-ME-BC in 1 capsule (60 capsules) |
| Concentration (test) |
Unspecified |
| Packaging |
Resealable container with 60 capsules |
| Storage |
Store in a dry place, at room temperature, away from light. |
| Molecular formula |
C12H10N2 |
| Molecular weight |
≈ 182.22 g mol⁻¹ |
| IUPAC name |
9-methyl-9H-pyrido[3,4-b]indole |
| CAS number |
Unspecified |
| Other names |
9-Methyl-β-carboline, 9-Me-BC, 9-MBC
|
In laboratory studies, 9-ME-BC has been linked to research in areas such as:
- modulation of the dopaminergic system and motivation,
- cognitive functions, learning and memory,
- neuroprotection and neuroplasticity,
- mitochondrial bioenergetics of neurons,
- resistance to fatigue and stress.
Possible side effects
- Insomnia or restlessness (especially with late administration in models)
- Headaches, nausea, dyspeptic complaints
- Rare autonomic manifestations (e.g. changes in blood pressure) depending on the protocol
Resources
- Review papers on β-carbolines and dopaminergic modulation (experimental studies)
- Publications on neuronal mitochondrial bioenergetics and oxidative stress (model systems)
- Studies on neuroplasticity and neuritogenesis after small molecule intervention
- Experimental work tracking cognitive parameters and motivation
- Methodological protocols for oral dosage models in capsule form
