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What is Epitalon
Epitalon is a synthetic analogue of the natural pineal peptide epithalamin. It is composed of four amino acids – alanine, glutamic acid, asparagine and glycine – and is among the research peptides studied in relation to the regulation of telomerase and the potential modulation of the aging process.
Effects investigated
- Telomerase and telomeres: Activation of telomerase and slowing of telomere shortening in cell cultures.
- Neuroprotection: Protection of neurons from oxidative stress and improvement of cognitive parameters in animals.
- Sleep rhythm and melatonin: Epitalon has an effect on circadian rhythm and melatonin levels.
- Immune balance: Potential immunomodulatory effects with long-term administration in experiments.
- Cellular renewal: Support of cell renewal and reduction of apoptosis frequency in some studies.
How Epitalon works
The mechanism of action of Epitalon is being investigated in the context of its effect on the activation of the enzyme telomerase – an enzyme that lengthens telomeres, the protective ends of chromosomes. Telomere shortening is associated with aging and cellular apoptosis. In addition, its neuroprotective, antioxidant and immunomodulatory properties are also being investigated.
Dosage in studies
- Dose: 1–5 mg daily
- Form: intramuscular or subcutaneous
- Frequency: 1× daily
- Duration: 10–20 days according to research protocol
Epitalon is a synthetic tetrapeptide that was developed based on the natural peptide epithalamine produced by the pineal gland. In scientific experiments, it is mainly studied for its effects on cell cycle regulation, telomerase activation and potential cell lifespan extension.
| Parameter | Value |
|---|---|
| Form | Lyophilized powder |
| Content | 10 mg (5.98 mg measured in the tested sample) |
| Purity | 98% (HPLC) |
| Packaging | Glass vial with cap |
| Storage | Store away from light at a temperature below 8 °C |
| Molecular formula | C14H22N4O9 |
| Molecular weight | 390.35 g·mol⁻¹ |
| IUPAC name | L-alanyl-L-glutamyl-L-asparaginyl-glycine |
| Other names | Epithalamin, Ala-Glu-Asp-Gly |
In laboratory studies, Epitalon is associated with research in areas such as:
- telomerase activation and telomere elongation,
- support of cellular stability and longevity,
- antioxidant and neuroprotective effects,
- normalization of the pineal rhythm (melatonin),
- potential effects in the area of healthy aging.
Possible side effects
- Mild irritation at the injection site
- Temporary fatigue or drowsiness
- Rarely reported headaches
Sources
- Khavinson, V. et al. (2003). Peptide Epitalon activates telomerase and elongates telomeres in human somatic cells
- Korkushko, O. V. et al. (2006). Epithalamin effects on biological age and lifespan
- Khavinson, V. Kh. (2002). The role of peptide bioregulators in aging and longevity
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