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Description
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Shipping
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Review
What is Ipamorelin
Ipamorelin is a pentalanide peptide from the GHRP (growth hormone releasing peptides) group. Compared to other secretagogues, it is unique in that it specifically stimulates growth hormone secretion without a concomitant increase in cortisol or prolactin. Its selectivity makes it an interesting candidate in scientific research related to hormonal balance, regeneration and metabolism.
Researched effects and interesting facts
- GH stimulation: increase in growth hormone levels without affecting cortisol
- Muscle protection: maintenance of muscle mass during caloric deprivation
- Tissue regeneration: faster healing of muscles and soft tissues
- Sleep quality: observed effect on deepening and prolonging sleep
- Hormonal balance: minimal activation of the ACTH or prolactin axes
How Ipamorelin works
Ipamorelin acts on ghrelin receptors (GHS-R) in the pituitary gland, where it stimulates the natural secretion of growth hormone. In preclinical studies, its effect was selective - it did not affect the HPA axis (hypothalamic-pituitary-adrenal), which means that it did not cause an increase in stress hormones. The mechanism of action involves the activation of signaling pathways related to cell renewal, metabolism, and anabolic processes.
Dosage in studies
- Dose: 200–500μg/kg daily
- Form: subcutaneous (s.c.)
- Frequency: 1–2× daily
- Duration: 14–28 days depending on the target
Ipamorelin is a synthetic peptide being studied as a selective growth hormone stimulator. It is scientifically significant in that it stimulates the pituitary gland without increasing cortisol or prolactin levels, making it a subject of interest in preclinical research focused on growth, regeneration and hormonal balance.
| Parameter | Value |
|---|---|
| Form | Lyophilised powder |
| Content of active ingredient | 10mg |
| Concentration (test) | 5.98mg |
| Packaging | Glass bottle with cap |
| Storage | 2-8°C, away from light |
| Molecular Formula | C38H49N9O5 |
| Molecular weight | 711.85g·mol⁻¹ |
| IUPAC name | Unspecified |
| CAS number | 170851-70-4 |
| Other names | Ipamorelin acetate |
In laboratory studies, Ipamorelin is associated with research in areas such as:
- stimulation of growth hormone secretion without affecting cortisol,
- preservation of muscle mass during catabolism,
- regeneration and restoration of damaged tissues,
- study of the effect on the sleep cycle,
- effect on hormonal balance without increasing prolactin.
Possible side effects
- Transient irritation at the injection site
- Mild fatigue or drowsiness
- Rarely edema or water retention
- No increase in cortisol or prolactin in preclinical models
Resources
- Møller, N. et al. (2003). "Ipamorelin stimulates GH without affecting ACTH or cortisol." J Clin Endocrinol Metab
- Jasper, M. et al. (2004). "The effect of ipamorelin on growth hormone release." Peptides
- van den Berghe, G. et al. (2001). "Neuroendocrine dysfunction in critically ill patients." Clin Endocrinol
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