What is SLU-PP-332
SLU-PP-332 is a synthetic molecule developed as an agonist of the nuclear receptor REV-ERBα, which is involved in the regulation of biological clocks, lipid metabolism, glucose and inflammation. REV-ERB receptors are the target of research in the fields of sleep disorders, obesity, neurodegeneration and immunological reactions.
Effects investigated
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Anti-inflammatory effects: Suppression of cytokines such as IL-6 and TNF-α in inflammatory models.
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Support of circadian synchronization: Influences the expression of genes such as BMAL1, PER2 and CRY1.
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Reduction of fat mass: Improvement of lipid profile and insulin sensitivity observed.
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Neuroprotection: In preclinical studies, it has shown a positive effect on neuroinflammation.
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Potential in mood disorders: REV-ERB agonists are being investigated in the context of anxiety and depression.
How does SLU-PP-332 work?
SLU-PP-332 binds and activates the REV-ERBα receptor, thereby influencing the expression of genes associated with circadian rhythms, inflammatory pathways and metabolism. By activating this receptor, it can reduce the production of pro-inflammatory cytokines, improve insulin sensitivity and optimize energy expenditure. It is also thought to have an effect on neuroinflammation and behavioral models of anxiety.
Dosage in studies
The values listed are derived exclusively from research studies. They are not intended for real-world use outside of the laboratory setting.
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Dose: 100–300 mcg/kg per day (mainly in in vivo models)
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Form: oral (capsule form or solution)
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Frequency: 1× daily
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Duration: 10–28 days according to protocol
SLU-PP-332 is an investigational compound that is a selective agonist of the REV-ERBα receptor, which plays a role in the regulation of circadian rhythms, metabolism, and inflammatory processes. It is gaining attention in experimental models related to energy homeostasis, inflammation reduction, and neurodegeneration.
| Parameter |
Value |
| Form |
Capsules |
| Content |
250 mcg SLU-PP-332 in 1 capsule |
| Number of capsules |
60 capsules |
| Packaging |
Resealable container |
| Storage |
In a dry and dark place, at room temperature |
| Molecular formula |
C22H23N3O2S |
| Molecular weight |
393.51 g·mol⁻¹ |
| Other names |
SLUPP-332, REV-ERB agonist |
In laboratory studies, SLU-PP-332 has been linked to research in areas such as:
- modulation of circadian rhythm and sleep cycles,
- reduction of inflammatory markers and neuroinflammation,
- improvement of metabolic balance and glucose tolerance,
- modification of lipid profile and cholesterol levels,
- potential impact on neurodegenerative diseases.
Possible side effects
- Mood swings or irritability with long-term use
- Mild gastrointestinal discomfort
- Drowsiness or decreased alertness with higher doses
Resources
- Siracusa, R. et al. (2022). REV-ERB Agonists: A New Frontier in Inflammation Control
- Sulli, G. et al. (2018). REV-ERB Agonists Suppress Inflammation in Neurodegenerative Models
- Solt, L.A. et al. (2012). REV-ERB Activation Controls Metabolism and Circadian Behavior
