Retatrutide - 10mg

What is Retatrutide?

Retatrutide is an experimental synthetic peptide that functions as an agonist of three different receptors: GLP-1 (glucagon-like peptide 1), GIP (glucose-dependent insulinotropic peptide) and glucagon receptor (GCGR). This combination makes it a so-called "triple agonist," with each of these receptors involved in regulating metabolism, energy expenditure, and glucose homeostasis. Retatrutide is being studied in connection with the treatment of obesity, metabolic syndrome and type 2 diabetes. In practice, this means that it is a substance that combines several effects at once - it suppresses appetite, supports energy expenditure and at the same time improves metabolic balance.

Researched effects and interesting facts

• Body weight loss of over 24% over 48 weeks in some phases of clinical trials.
• Appetite reduction after the first application.
• Improvement of insulin sensitivity and reduction of fasting glucose levels.
• Protective effects on cardiometabolic markers - blood pressure, triglycerides, CRP.
• Potential for use also in the field of neuroendocrine disorders.

How does Retatrutide work?

The mechanism of action of Retatrutide lies in its ability to activate three important hormonal pathways:

• GLP-1: Reduces appetite, slows gastric emptying and increases insulin secretion.
• GIP: Enhances the response of pancreatic beta cells to glucose and affects fat storage.
• Glucagon receptor: Increases energy expenditure, stimulates lipolysis and affects glucose metabolism.

Dosage in studies

The data below come from clinical and preclinical research. This is not a recommended dosage.

• Dose: 0.5–12 mg per week
• Form of administration: subcutaneous (under the skin) injection
• Frequency: 1× per week
• Duration: 8–48 weeks depending on the study

Retatrutide is a synthetic peptide agonist of three receptors – GLP-1, GIP and glucagon receptor. It is being studied in the laboratory for its potential to influence energy metabolism, appetite and glucose regulation.

• appetite reduction and energy intake regulation,
• support of weight loss and fat reduction,
• improvement of insulin sensitivity and glucose tolerance,
• research into the treatment of type 2 diabetes,
• activation of glucagon and incretin pathways.